The Science of Calm
How DailyCalm's Clinically-Proven Formula Breaks the Stress Cycle at the Molecular Level
Third-Party Tested
Published Research
GMP Certified
Understanding Your Body's Stress Response
Before we dive into how SuperCalm works, let's understand what's happening inside your body when you're stressed.
The Cortisol Cascade: Your Body Under Stress
When you encounter a stressor, whether it's a work deadline, traffic jam, or relationship conflict,
your body initiates a sophisticated biochemical response:
Step 1: Threat Detection
Your hypothalamus perceives the stressor and releases Corticotropin-Releasing Hormone (CRH)
Step 2: Signal Amplification
CRH triggers your pituitary gland to secrete Adrenocorticotropic Hormone (ACTH)
Step 3: Cortisol Release
ACTH stimulates your adrenal glands to pump cortisol into your bloodstream
Step 4: Systemic Impact
Elevated cortisol increases heart rate, blood pressure, blood sugar, and suppresses non-essential functions like digestion and immune response
The Problem!
This response was designed for short-term, life-threatening situations. But in modern life, chronic activation of this system leads to persistently elevated cortisol levels—contributing to anxiety, poor sleep, weight gain, weakened immunity, and cognitive decline.
90%
Cortisol Increase During Stress
Study on 107 students during exam periods
77%
Adults Report Physical Stress Symptoms
American Psychological Association, 2023
60%
Of Stressed Individuals Have Mg Deficiency
Akarachkova et al., 2019
Breaking the Cascade: Multi-Level Intervention
Now that you understand the cortisol cascade, here's how SuperCalm interrupts it at every critical stage.
The Problem with Single-Ingredient Solutions:
The Problem with Single-Ingredient Solutions:
Most stress supplements target only one pathway. But your stress response is a complex cascade—it requires intervention at multiple levels simultaneously.
⚡ Acute Response – Minutes to Hours
🧠 Neurotransmitter – GABA & Glutamate Balance
🎯 Hormonal Control – HPA Axis Regulation
🛡️ System Support – Mood & Recovery
DailyCalm's approach:
Four clinically-dosed ingredients working synergistically across all four intervention points—from immediate relief to long-term cortisol regulation.
The Four-Ingredient System
of DAILY CALM
Each ingredient targets a specific stage in the stress cascade.
Together, they create comprehensive cortisol control.
1. L-Theanine
200mg per serving
Reduces cortisol response to stress
Increases alpha brain wave activity
Effects felt within 30-60 minutes
Non-sedating calm focus
Rapid Stress Interruption
Crosses the blood-brain barrier in 30 minutes. Reduces cortisol response and increases alpha brain waves (8-13 Hz) for "relaxed alertness"—calm focus without sedation.
🔬 Clinical Evidence
200mg L-theanine significantly increased alpha wave activity (p≤0.050) and reduced cortisol response to stress within 3 hours. 28-day supplementation: 21% cognitive performance improvement, reduced perceived stress, improved sleep quality. Safe with no serious adverse events.
Benson et al. (2021), PMC8475422; Lim et al. (2024), PubMed: 38758503
2. Ashwagandha Root Extract
200mg per serving
Reduces cortisol by up to 30%
Adaptogenic stress protection
Supports HPA axis regulation
5,000+ years of traditional use
HPA Axis Regulation: Cortisol Control at the Source
As an adaptogen, Ashwagandha modulates your HPA axis—the hormonal control center that regulates cortisol production. Unlike acute stress relief, this builds long-term resilience over 4-8 weeks.
🔬 Clinical Evidence: Up to 30% Cortisol Reduction
🔬 Clinical Evidence: Up to 30% Cortisol Reduction
Meta-analysis of 9 RCTs (558 patients): Ashwagandha reduced serum cortisol by mean -2.58 (p<0.0001), with individual studies showing 14.5-32.6% reductions. 60-day trials demonstrated 27.9% cortisol decrease (P=0.0006), alongside significant reductions in morning cortisol, DHEA-S, and perceived stress (-4.88 points, p=0.0013).
Lopresti et al. (2019), PMC6750292; Baba et al. (2024), PMC12242034
3. Magnesium Glycinate
200mg Elemental Magnesium
Regulates GABA receptors
Blocks NMDA overactivation
Highest bioavailability form
Essential nervous system mineral
Dual-Action Neurotransmitter Balance
Magnesium enhances GABA (calming neurotransmitter) while blocking overactive NMDA receptors (excitatory). 60% of stressed individuals are deficient—creating a vicious cycle. Glycinate form offers superior bioavailability without digestive issues.
🔬 Clinical Evidence: GABA Pathways & Stress Depletion
Research confirms magnesium's anxiolytic effects via GABA-A receptor mechanisms (same pathways as benzodiazepines, without side effects). Systematic review of 18 studies: beneficial effects on anxiety in vulnerable populations. Stress depletes magnesium through urinary loss; 60% of chronically stressed women showed deficiency with symptoms of irritability, fatigue, and sleep disorders.
Boyle et al. (2017), PMC5452159; Pickering et al. (2020), PMC7761127
4. Vitamin D3 (Cholecalciferol)
1,000 IU (130% DV)
Supports serotonin synthesis
Modulates mood regulation
Reduces nervous system inflammation
Widespread deficiency in modern populations
Mood & Nervous System Support
Vitamin D3 is a neurosteroid hormone that regulates serotonin synthesis and reduces nervous system inflammation. Widespread deficiency makes it essential for comprehensive stress management and mood regulation.
The Synergy:
Why the Combination Matters
DailyCalm isn't just four ingredients
it's a precisely calibrated system where each component amplifies the others' effects.
Multi-Pathway Stress Intervention
While other products focus on a single mechanism (usually just GABA or just cortisol), Daily Calm simultaneously addresses multiple pathways in the stress response cascade:
Acute Stress Response (Minutes):
L-Theanine provides immediate relief by reducing the cortisol spike and promoting alpha wave activity for calm focus.
Neurotransmitter Balance (Hours):
Magnesium Glycinate + L-Theanine create a powerful GABA-enhancing combination while blocking excitatory NMDA receptors.
Hormonal Regulation (Days-Weeks):
Ashwagandha resets your HPA axis, preventing excessive cortisol production at the source—building long-term stress resilience.
Mood & Recovery (Ongoing):
Vitamin D3 supports serotonin synthesis and reduces neuroinflammation, optimizing your brain's stress recovery systems.
Why Trust Daily Calm?
Our Commitment to Scientific Rigor
🔬
Acute Stress Response (Minutes):
L-Theanine provides immediate relief by reducing the cortisol spike and promoting alpha wave activity for calm focus.
✓
Third-Party Tested
Every batch is tested by independent laboratories for purity, potency, and safety. We test for heavy metals, microbial contamination, and verify that each ingredient meets our strict specifications.
🔬
GMP Certified Manufacturing
Manufactured in the USA in facilities that exceed FDA Good Manufacturing Practice standards. Our supply chain is fully traceable and audited.
📊
Clinical Dosing
We use the exact dosages shown to be effective in clinical trials—200mg L-theanine, 100mg Ashwagandha extract, 200mg elemental magnesium from glycinate, 1,000 IU vitamin D3.
🌿
100% Natural
No artificial colors, flavors, or preservatives. No synthetic fillers. Just clinically-proven natural ingredients in their most bioavailable forms.
🎯
Transparent Labeling
Full ingredient disclosure. No proprietary blends. We tell you exactly what's in each serving and why it's there, backed by scientific citations.
Understanding Your Body's Stress Response
Break the cortisol cycle. Feel calm within 30 minutes. Build resilience in 4 weeks. 0g sugar • Third-party tested
Scientific References
L-Theanine Studies:
Williams, J.L., Everett, J.M., D'Cunha, N.M., et al. (2016). "Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink." Nutrients, 8(1), 53. PMC4728665
Benson, S., Downey, L.A., Stough, C., et al. (2021). "A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress." Neurology and Therapy, 10(2), 1061-1078. PMC8475422
Lim, L.L., Garneau, B., Jones, D., et al. (2024). "Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress." Neurology and Therapy. PubMed: 38758503
Ashwagandha Studies:
Lopresti, A.L., Smith, S.J., Malvi, H., Kodgule, R. (2019). "An Investigation into the Stress-Relieving and Pharmacological Actions of an Ashwagandha Extract." Medicine (Baltimore), 98(37). PMC6750292
Chandrasekhar, K., Kapoor, J., Anishetty, S. (2012). "A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults." Indian Journal of Psychological Medicine, 34(3), 255-262. PubMed: 23439798
Baba, G., Al-Shoumer, K., et al. (2024). "Effects of Ashwagandha Supplements on Cortisol, Stress, and Anxiety Levels in Adults: A Systematic Review and Meta-Analysis." Cureus, 16(11). PMC12242034
Salve, J., Pate, S., Debnath, K., Langade, D. (2019). "Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults." Cureus, 11(12). PMC6979308
Magnesium Studies:
Boyle, N.B., Lawton, C., Dye, L. (2017). "The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review." Nutrients, 9(5), 429. PMC5452159
Pickering, G., Mazur, A., Trousselard, M., et al. (2020). "Magnesium Status and Stress: The Vicious Circle Concept Revisited." Nutrients, 12(12), 3672. PMC7761127
Poleszak, E., Szewczyk, B., Kędzierska, E., et al. (2008). "Benzodiazepine/GABA(A) Receptors are Involved in Magnesium-Induced Anxiolytic-Like Behavior in Mice." Pharmacological Reports, 60(4), 483-489. PubMed: 18799816
Serefko, A., Szopa, A., Poleszak, E. (2016). "Magnesium in Neuroses and Neuroticism." In: Vink, R., Nechifor, M. (eds) Magnesium in the Central Nervous System. NCBI Bookshelf, NBK507254